L
Leroy F. Liu
Researcher at Johns Hopkins University School of Medicine
Publications - 2
Citations - 870
Leroy F. Liu is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Chemotherapy & Camptothecin. The author has an hindex of 2, co-authored 2 publications receiving 866 citations.
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Journal ArticleDOI
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts
Beppino C. Giovanella,John S. Stehlin,Monroe E. Wall,Mansukh C. Wani,Allan W. Nicholas,Leroy F. Liu,Robert Silber,Milan Potmesil +7 more
TL;DR: Unlike other anticancer drugs tested, 20(RS)-9-amino-camptothecin (9-AC) induced disease-free remissions and the overall drug toxicity was low and allowed for repeated courses of treatment.
Book ChapterDOI
DNA topoisomerases as anticancer drug targets.
TL;DR: This chapter discusses the DNA topoisomerases as anticancer drug targets and the signals and events involved in cell killing, in particular the early signals induced by drug-mediated DNA damage.