M
Monroe E. Wall
Researcher at RTI International
Publications - 46
Citations - 1887
Monroe E. Wall is an academic researcher from RTI International. The author has contributed to research in topics: Camptothecin & Topoisomerase. The author has an hindex of 21, co-authored 46 publications receiving 1846 citations. Previous affiliations of Monroe E. Wall include National Institutes of Health.
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Journal ArticleDOI
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts
Beppino C. Giovanella,John S. Stehlin,Monroe E. Wall,Mansukh C. Wani,Allan W. Nicholas,Leroy F. Liu,Robert Silber,Milan Potmesil +7 more
TL;DR: Unlike other anticancer drugs tested, 20(RS)-9-amino-camptothecin (9-AC) induced disease-free remissions and the overall drug toxicity was low and allowed for repeated courses of treatment.
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Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal
Monroe E. Wall,Mansukh C. Wani,D.M. Brown,Fekadu Fullas,J.B. Olwald,F.F. Josephson,N.M. Thornton,John M. Pezzuto,Chris Beecher,Norman R. Farnsworth,Geoffrey A. Cordell,A. D. Kinghorn +11 more
TL;DR: It was concluded that the activity initially observed was primarily due to tannins, and procedures are presented for routinely obtaining tannin-free organic and aqueous fractions.
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Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity.
Monroe E. Wall,Mansukh C. Wani,Susan L. Morris Natschke,Susan L. Morris Natschke,Allan W. Nicholas +4 more
TL;DR: Antitumor activity of racemic 4 in L1210 leukemia in mice was considerably greater than that of natural (20S)-camptothecin and its sodium salt and there was also no toxic effect observed even at relatively high doses.
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Novel strategies for the discovery of plant-derived anticancer agents
A. D. Kinghorn,Norman R. Farnsworth,Djaja D. Soejarto,Geoffrey A. Cordell,John M. Pezzuto,George Udeani,M. C. Wani,Monroe E. Wall,Hernán A. Navarro,Robert Kramer,Ana T. Menendez,Craig R. Fairchild,K. E. Lane,Salvatore Forenza,D. M. Vyas,Kin Sing Lam,Yue-Zhong Shu +16 more
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Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells
Maurizio Del Poeta,Shih-Fong Chen,Daniel D. Von Hoff,Christine C. Dykstra,Mansukh C. Wani,Govindarajan Manikumar,Joseph Heitman,Monroe E. Wall,John R. Perfect +8 more
TL;DR: The results suggest that camptothecin and/or nitidine derivatives can exhibit potent antifungal activity and that the activities of camPTothecin derivatives with existing antifundal drugs may be synergistic against pathogenic fungi.