Lesley C. Wright

TL;DR: In this paper, neutral lipid domains are intercalated with the bilayer lipid of the plasma membrane and a functional role for these neutral lipids is also proposed based on plasma membrane alterations which occur with cellular stimulation, with the acquisition of resistance to anti-cancer drugs, and in metastatic cells.

TL;DR: In this paper, high-resolution proton nuclear magnetic resonance (NMR) studies of intact cancer cells revealed differences between cells with the capacity to metastasize and those that produce locally invasive tumors.

TL;DR: Plasma membranes purified 32‐ to 45‐fold were isolated from leukaemic T‐lymphoblasts, both sensitive and resistant to the Vinca alkaloid vinblastine, and on development of drug resistance there was a very significant elevation of ether lipid content.

TL;DR: The long T2 relaxation value in the MRS profile, found in isolated proteolipid and unfractionated plasma and serum of other patients with carcinoma of the ovary and colon, provides a non-invasive method of assaying for cancer.

TL;DR: An increase in the plasma levels of apoprotein B‐containing lipoproteins is the basis of the magnetic resonance (MR) test for cancer, but plasma from patients with hyperlipidemia unrelated to cancer also show narrow MR line widths and are therefore a confounding variable.