L
Leslie E. Orgel
Researcher at Salk Institute for Biological Studies
Publications - 303
Citations - 24848
Leslie E. Orgel is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Nucleic acid & RNA. The author has an hindex of 80, co-authored 303 publications receiving 23937 citations. Previous affiliations of Leslie E. Orgel include Scripps Research Institute.
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Selfish DNA: the ultimate parasite
Leslie E. Orgel,Francis Crick +1 more
TL;DR: The DNA of higher organisms usually falls into two classes, one specific and the other comparatively nonspecific, and it seems plausible that most of the latter originated by the spreading of sequences which had little or no effect on the phenotype.
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Prebiotic Chemistry and the Origin of the RNA World
TL;DR: The demonstration that ribosomal peptide synthesis is a ribozyme-catalyzed reaction makes it almost certain that there was once an RNA World, and a discussion of genetic systems simpler than RNA that might have "invented" RNA is discussed.
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Evolution of the genetic apparatus.
TL;DR: It is argued that the evolution of the genetic apparatus must have required the abiotic formation of macromolecules capable of residue-by-residue replication, and suggests that polynucleotides were present even in the most primitive ancestors of contemporary organisms.
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Synthesis of long prebiotic oligomers on mineral surfaces
TL;DR: This work describes a system that models prebiotic polymerization by the oligomerization of activated monomers—both nucleotides and amino acids, and finds that whereas the reactions in solution produce only short oligomers, the presence of mineral surfaces induces the formation of oligomers up to 55 monomers long.