Li Li

TL;DR: The roles of Notch signaling pathway in tumor metastasis and its regulatory mechanisms are summarized and the current treatment strategies targeting Notch signal pathway are discussed.

TL;DR: Cav-1 is mechanosensitive to LSS exposure, and its activation-induced PI3K/Akt/mTOR signaling promotes motility, invadopodia formation and metastasis of breast carcinoma MDA-MB-231 cells, and Cav-1 knockdown significantly suppressed tumor colonization in the lungs and distant metastases in animal models.

TL;DR: It is demonstrated that activation of Notch-1 signaling pathway promoted the malignant behaviors of MDA-MB-231 cells such as increased cell proliferation, colony formation, adhesion, migration, and invasion, and inhibited apoptosis; whereas deactivation of this signaling pathway led to the reversal of the aforementioned malignant cellular behaviors.

TL;DR: Ti2O3 nanoparticles are proposed as a pure Ti3+ system that performs efficiently toward NH3 electrosynthesis under ambient conditions and significantly lowered the overpotential of the potential-determining step.

TL;DR: F folate (FA) receptor targeted magnetic-mesoporous silica nanoparticles for the codelivery of VEGF shRNA and doxorubicin (DOX) (denoted as M-MSN(DOX)/PEI-FA/VEGF shRNA) provided a potential strategy to treat cancer by a singular nanoparticle delivery system.