L
Li Lin
Researcher at Université de Montréal
Publications - 2
Citations - 440
Li Lin is an academic researcher from Université de Montréal. The author has contributed to research in topics: Motor neuron & Zebrafish. The author has an hindex of 2, co-authored 2 publications receiving 408 citations.
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Journal ArticleDOI
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
Edor Kabashi,Li Lin,Miranda L. Tradewell,Patrick A. Dion,Valérie Bercier,Patrick Bourgouin,Daniel Rochefort,Samar Bel Hadj,Heather D. Durham,Christine Vande Velde,Guy A. Rouleau,Pierre Drapeau +11 more
TL;DR: Together these approaches showed that TARDBP mutations cause motor neuron defects and toxicity, suggesting that both a toxic gain of function as well as a novel loss of function may be involved in the molecular mechanism by which mutant TDP-43 contributes to disease pathogenesis.
Journal ArticleDOI
Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish
François Gros-Louis,Jasna Kriz,Edor Kabashi,Jonathan R. McDearmid,Stéphanie Millecamps,Makoto Urushitani,Li Lin,Patrick A. Dion,Qinzhang Zhu,Pierre Drapeau,Jean-Pierre Julien,Guy A. Rouleau +11 more
TL;DR: It is speculated that the newly identified Als1 mRNA species prevent the Als2 KO mice from developing severe neurodegenerative disease and might also regulate the severity of the motor neurons phenotype observed in ALS2 patients.