L
Li Ming Chen
Researcher at Sun Yat-sen University
Publications - 33
Citations - 1408
Li Ming Chen is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: P-glycoprotein & Multiple drug resistance. The author has an hindex of 18, co-authored 33 publications receiving 1326 citations. Previous affiliations of Li Ming Chen include St. John's University.
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Journal ArticleDOI
Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2
Chun Ling Dai,Amit K. Tiwari,Chung-Pu Wu,Xiao Dong Su,Si Rong Wang,Dong Geng Liu,Charles R. Ashby,Yan Huang,Robert W. Robey,Yong Ju Liang,Li Ming Chen,Cheng Jun Shi,Suresh V. Ambudkar,Zhe-Sheng Chen,Li Wu Fu +14 more
TL;DR: Investigation of the ability of lapatinib to reverse tumor multidrug resistance (MDR) due to overexpression of ABC subfamily B member 1 (ABCB1) and ABCsubfamily G member 2 (ABCG2) transporters found it reverses ABCB1- and ABCG2-mediated MDR by directly inhibiting their transport function.
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Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance
TL;DR: Results suggest that Tet is a potent MDR-reversing agent in vitro and in vivo, and its mechanism of action is via directly binding to P-gp and increasing intracellular VCR accumulation.
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Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo
Zhi Shi,Yong Ju Liang,Zhe-Sheng Chen,Xiu Wen Wang,Xiao Hong Wang,Yan Ding,Li Ming Chen,Xiao Ping Yang,Li Wu Fu +8 more
TL;DR: The results suggest that administration of RNAi targeted MDR1 gene can effectively reverse MDR both in vitro and in vivo models.
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Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function
Li Sheng Zheng,Fang Wang,Yu Hong Li,Xu Zhang,Li Ming Chen,Yong Ju Liang,Chun Ling Dai,Yan Yan Yan,Li Yang Tao,Yan Jun Mi,An Kui Yang,Kenneth K.W. To,Li Wu Fu +12 more
TL;DR: Vandetanib overcomes ABCC1- and ABCG2-mediated drug resistance by inhibiting the transporter activity, independent of the blockade of AKT and ERK1/2 signal transduction pathways.
Journal ArticleDOI
Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi.
Jian Ye Zhang,Li Yang Tao,Yong Ju Liang,Li Ming Chen,Yan Jun Mi,Li Sheng Zheng,Fang Wang,Zhigang She,Yong Cheng Lin,Kenneth K.W. To,Li Wu Fu +10 more
TL;DR: It is demonstrated that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction, and the structure-activity relationships of these compounds are discussed.