Charles R. Ashby

TL;DR: The development of new compounds and the re-evaluation of compounds originally designed for other targets as transport inhibitors of ATP-dependent drug efflux pumps are summarized.

TL;DR: It is speculated that because the experience of the high is associated with the fast uptake of cocaine and methylphenidate in the brain, the slow clearance ofethylphenidate from the brain may serve as a limiting factor in promoting its frequent self-administration.

TL;DR: The critical and targetable redox-regulating enzymes, including mitochondrial electron transport chain complexes, NADPH oxidases (NOXs), enzymes related to glutathione metabolism, glutamate/cystine antiporter xCT, thioredoxin reductases (TrxRs), nuclear factor erythroid 2-related factor 2 (Nrf2), and their roles in regulating cellular ROS levels, drug resistance as well as their clinical significance are discussed.

TL;DR: Investigation of the ability of lapatinib to reverse tumor multidrug resistance (MDR) due to overexpression of ABC subfamily B member 1 (ABCB1) and ABCsubfamily G member 2 (ABCG2) transporters found it reverses ABCB1- and ABCG2-mediated MDR by directly inhibiting their transport function.

TL;DR: The results obtained with highly selective D3 receptor antagonists such as SB-277011-A, SB-414796, and NGB-2904 indicate that central D3 receptors may play an important role in drug-induced reward, drug-taking, and cue-, drug- and stress-induced reinstatement of drug-seeking behavior.