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Li-She Gan

Researcher at Zhejiang University

Publications -  131
Citations -  2325

Li-She Gan is an academic researcher from Zhejiang University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 25, co-authored 114 publications receiving 1769 citations. Previous affiliations of Li-She Gan include Sun Yat-sen University & Wuyi University.

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Alkaloids from the Root of Isatis indigotica

TL;DR: Seventeen new alkaloids and 14 known analogues have been isolated from an aqueous extract of the root of Isatis indigotica by extensive spectroscopic data analysis, including 2D NMR, single-crystal X-ray crystallography using anomalous scattering of Cu Kα radiation, and electronic circular dichroism spectra calculations based on the quantum-mechanical time-dependent density functional theory.
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Isocoumarin derivatives and benzofurans from a sponge-derived Penicillium sp. fungus.

TL;DR: Ten new fungal metabolites, including three hydroisocoumarins, penicimarins A-C, and four benzofurans, peniifurans A-D, together with four known isocou marin derivatives (4, 5, 9, 10), were obtained from the sponge-derived fungus Penicillium sp.
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Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.

TL;DR: A new enantiomeric pair of spirodiketones, (+)- and (-)-denobilone A (1 and 2), three new phenanthrene derivatives (3-5), and three new biphenanthrenes (22-24), along with 11 known phenanthene derivatives (6-16), five known bibenzyl derivatives (17-21), and four known biphenAnthrenes
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Sesquiterpene lactones from the root tubers of Lindera aggregata.

TL;DR: Five new sesquiterpene lactones, linderagalactones A-E (1-5), linderane, hydroxylindestenolide, and linderalactone showed hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with EC(50) values of 67.5, 167.4, and 98.0 microM, respectively.
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Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.

TL;DR: Four new 9',10'-dihydro-biphenanthrenes, including an unprecedented 1,2'-linked biphenanthrene, are isolated from a 95% ethanol extract of the fibrous roots of Bletilla striata and showed potent antibacterial activities against six Gram-positive bacterial strains.