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Yu-Huan Li
Researcher at Peking Union Medical College
Publications - 140
Citations - 2662
Yu-Huan Li is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 26, co-authored 117 publications receiving 2002 citations. Previous affiliations of Yu-Huan Li include National Health and Family Planning Commission.
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Journal ArticleDOI
Alkaloids from the Root of Isatis indigotica
Minghua Chen,Li-She Gan,Sheng Lin,Xiaoliang Wang,Li Li,Yu-Huan Li,Cheng-Gen Zhu,Yanan Wang,Bingya Jiang,Jian-Dong Jiang,Yongchun Yang,Jiangong Shi +11 more
TL;DR: Seventeen new alkaloids and 14 known analogues have been isolated from an aqueous extract of the root of Isatis indigotica by extensive spectroscopic data analysis, including 2D NMR, single-crystal X-ray crystallography using anomalous scattering of Cu Kα radiation, and electronic circular dichroism spectra calculations based on the quantum-mechanical time-dependent density functional theory.
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Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis.
TL;DR: Alkaloids 2, 6, 11, and 13 exhibited antiviral activity against the Coxsackie virus B3 (CVB3), and alkaloids 7, 8, and 17 inhibited influenza virus A/Hanfang/359/95 (H3N2) replication with IC50 values of 63.46 μM.
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Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance.
Yu-Ping Wang,Wei Zhao,Rong Xue,Zhen-Xian Zhou,Fei Liu,Yan-Xing Han,Gang Ren,Zong-Gen Peng,Shan Cen,Hong-Shan Chen,Yu-Huan Li,Jian-Dong Jiang +11 more
TL;DR: Combination of OMTR with lamivudine prevented HBV from developing drug resistance, and enhanced anti-HBV effect as compared to lamivUDine monotherapy.
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Enantiomers of an Indole Alkaloid Containing Unusual Dihydrothiopyran and 1,2,4-Thiadiazole Rings from the Root of Isatis indigotica
Minghua Chen,Sheng Lin,Li Li,Cheng-Gen Zhu,Xiaoliang Wang,Yanan Wang,Bingya Jiang,Sujuan Wang,Yu-Huan Li,Jian-Dong Jiang,Jiangong Shi +10 more
TL;DR: A pair of enantiomers of an indole alkaloid containing dihydrothiopyran and 1,2,4-thiadiazole rings was isolated from an aqueous extract of the root of Isatis indigotica by extensive spectroscopic analysis.
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Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro.
TL;DR: The antiviral mechanism of GA appears to be associated with Hsp90 inactivation and cell cycle restoration, which indicates that GA exhibits broad-spectrum antiviral activity.