Minghua Chen

TL;DR: Seventeen new alkaloids and 14 known analogues have been isolated from an aqueous extract of the root of Isatis indigotica by extensive spectroscopic data analysis, including 2D NMR, single-crystal X-ray crystallography using anomalous scattering of Cu Kα radiation, and electronic circular dichroism spectra calculations based on the quantum-mechanical time-dependent density functional theory.

TL;DR: A pair of enantiomers of an indole alkaloid containing dihydrothiopyran and 1,2,4-thiadiazole rings was isolated from an aqueous extract of the root of Isatis indigotica by extensive spectroscopic analysis.

TL;DR: In preliminary analgesic and toxicity assays, the isomer with ring A in the chair conformation was found to be more active than that with ring B in the boat conformation, and 15, 16, and 19 showed neuroprotective activity.

TL;DR: This study shows that F12016 is a non-TZD, novel selective PPARγ agonist without the classical lipogenic side effects, which may provide a new structural strategy for designing PPAR γ ligands with advantages over TZDs.

TL;DR: Seven new glycosidic bisindole alkaloids, isatindigobisindolosides A–G (1–7), were isolated from an aqueous extract of the Isatis indigotica roots and showed antiviral activity against both the influenza virus A/Hanfang/359/95 (H3N2) and Coxsackie virus B3 with IC50 values of 8.4–100.0 μM.