Li Sun

TL;DR: Investigation revealed that β-catenin transcriptionally regulated Pit1, a necessary player in VSMC osteogenic phenotype change and calcification, is an important player in high phosphorus level-induced aortic calcification in CKD.

TL;DR: There was a progressive loss of PTCs in the AAN model, which was associated with the decreased expression of VEGF and a significant increase in nuclear localization of HIF-1α was seen 16 weeks after treatment with CAM decoction in the context of severe tubulointerstitial damage.

TL;DR: Pioglitazone attenuated renal injury and improved renal function and upregulated the expression levels of ATP synthase β, COX I and NDUFB8, which were downregulated in the kidney of Nx rats and TGF-β1-exposed HK-2 cells, which suggests that these effects at least partly PPARγ dependent.

TL;DR: O3FA supplementation is associated with lower several serum lipids and vascular inflammation markers in patients with ESRD, and has no significant effect on TC, HDL, albumin, hemoglobin, homocysteine, DBP, glucose, lipoprotein(a), and ferritin.

TL;DR: This study demonstrates that pioglitazone benefits renal failure through activation of the antioxidative system and inhibition of angiogenesis in the injured kidney.