Li Xu

TL;DR: The findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.

TL;DR: This study is the first to demonstrate the existence of high levels of mobile genes conferring reduced susceptibility to fluoroquinolones as well as the presence of ESBL genes in fish produced in China, and identifies a significant reservoir of antibiotic resistance genes relevant to human medicine.

TL;DR: A novel multiplex PCR assay is described that allows rapid detection of bla(CTX-M) genes and discrimination between groups 1, 2, 9 and 25/26 and enhances the assay by saving time and costs.

TL;DR: If the rising trend in carriage of bacteria producing ESBLs continues, guidelines for empirical therapy for patients presenting from the community may need to be modified and the findings raise the concern that the pattern and routes of spread of CTX-M-15 may be replicated in the future by broader-spectrum β-lactamases, such as New Delhi metallo-β-lacticamase ('NDM-1').

TL;DR: The CTX-M-15-producing RE1 clone (strain A) is the predominant clone in the West Midlands and has spread throughout the region since its emergence in an outbreak 3 years earlier, showing the rapid spread and diversification of CTX/M-producing Enterobacteriaceae over a 3 year period.