L
Li-Yu Chen
Researcher at National Taiwan University
Publications - 1
Citations - 139
Li-Yu Chen is an academic researcher from National Taiwan University. The author has contributed to research in topics: Vimentin & Gene knockdown. The author has an hindex of 1, co-authored 1 publications receiving 78 citations.
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Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI.
Chien-Hui Weng,Li-Yu Chen,Yu-Chin Lin,Jin-Yuan Shih,Yun-Chieh Lin,Ruo-Yu Tseng,An-Chieh Chiu,Yu-Hsuan Yeh,Chi Liu,Yi-Ting Lin,Jim-Min Fang,Ching-Chow Chen +11 more
TL;DR: It is reported that NSCLC cells with acquired resistance to gefitinib or osimertinib (AZD9291) exhibit EMT features, with a decrease in E-cadherin, and increases in vimentin and stemness, without possessing any EGFR secondary mutations.