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Yu-Chin Lin
Researcher at National Taiwan University
Publications - 10
Citations - 562
Yu-Chin Lin is an academic researcher from National Taiwan University. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 9, co-authored 9 publications receiving 462 citations. Previous affiliations of Yu-Chin Lin include Memorial Hospital of South Bend & National Yang-Ming University.
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Journal ArticleDOI
Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3
Kuen-Feng Chen,Wei Tien Tai,Tsung Hao Liu,Hsiang-Po Huang,Yu-Chin Lin,Chung Wai Shiau,Pui-Kai Li,Pei-Jer Chen,Ann-Lii Cheng +8 more
TL;DR: Sorafenib sensitizes resistant HCC cells to TRAIL-induced apoptosis at clinical achievable concentrations, and this effect is mediated via the inhibition of STAT3.
Journal ArticleDOI
Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI.
Chien-Hui Weng,Li-Yu Chen,Yu-Chin Lin,Jin-Yuan Shih,Yun-Chieh Lin,Ruo-Yu Tseng,An-Chieh Chiu,Yu-Hsuan Yeh,Chi Liu,Yi-Ting Lin,Jim-Min Fang,Ching-Chow Chen +11 more
TL;DR: It is reported that NSCLC cells with acquired resistance to gefitinib or osimertinib (AZD9291) exhibit EMT features, with a decrease in E-cadherin, and increases in vimentin and stemness, without possessing any EGFR secondary mutations.
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CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells
TL;DR: It is disclosed that bortezomib induced apoptosis of HNSCC cells in vitro and in vivo through inhibition of cancerous inhibitor of protein phosphatase 2A (CIP2A)-mediated PP2A dependent Akt activation.
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Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress
Yu-Chin Lin,Meng-Hsuan Wu,Tzu-Tang Wei,Yun-Chieh Lin,Wen-Chih Huang,Liang-Yu Huang,Yi-Ting Lin,Ching-Chow Chen +7 more
TL;DR: It is demonstrated that AMPK-dependent ER stress plays a crucial role in the anti-cancer effect of dasatinib in HNSCC and further activation of AMPK by metformin might enhance dasatisatinib efficacy.
Journal ArticleDOI
Degradation of Epidermal Growth Factor Receptor Mediates Dasatinib-Induced Apoptosis in Head and Neck Squamous Cell Carcinoma Cells
Yu-Chin Lin,Meng-Hsuan Wu,Tzu-Tang Wei,Shu-Hui Chuang,Kuen-Feng Chen,Ann-Lii Cheng,Ching-Chow Chen +6 more
TL;DR: In this article, the degradation of the epidermal growth factor receptor (EGFR) was found to be a determinant of dasatinib sensitivity to head and neck squamous cell carcinoma.