Liam Good

TL;DR: It is demonstrated here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents, and LNA/DNA copolymers exhibited potent antisense activity on assay systems as disparate as a G-protein-coupled receptor in living rat brain and an Escherichia coli reporter gene.

TL;DR: Results indicate that peptides can be used to carry antisense PNA agents into bacteria and open exciting possibilities for anti-infective drug development and provide new tools for microbial genetics.

TL;DR: The results demonstrate gene- and sequence-specific antisense inhibition in E. coli and open possibilities for anti-sense antibacterial drugs and gene function analyses in bacteria.

TL;DR: It is reported that PNAs targeted to functional and accessible sites in ribosomal RNA can inhibit translation in an Escherichia coli cell-free transcription/translation system, with 50% reductions caused by nanomolar PNA concentrations.

TL;DR: How the widely used antimicrobial polyhexamethylene biguanide kills bacteria selectively over host cells is examined and selective chromosome condensation provides an unanticipated paradigm for antimicrobial action that may not succumb to resistance.