Josephine Lai

TL;DR: It is demonstrated here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents, and LNA/DNA copolymers exhibited potent antisense activity on assay systems as disparate as a G-protein-coupled receptor in living rat brain and an Escherichia coli reporter gene.

TL;DR: Test the hypothesis that CB(2) receptor activation stimulates release from keratinocytes of the endogenous opioid beta-endorphin, which then acts at local neuronal mu-opioid receptors to inhibit nociception and indicates anatomical specificity of opioid effects.

TL;DR: Conditioned place preference is used to concomitantly determine the presence of tonic pain in rats and the efficacy of agents that relieve it and provides a new approach for investigating tonicPain in animals and for evaluating the analgesic effects of drugs.

TL;DR: AM1241 dose-dependently reversed tactile and thermal hypersensitivity produced by ligation of the L5 and L6 spinal nerves in rats, demonstrating a mechanism leading to the inhibition of pain, one that targets receptors localized exclusively outside the CNS.

TL;DR: It is shown that intrathecal administration of specific antisense oligodeoxynucleotides (ODN) to the peripheral tetrodotoxin (TTX)‐resistant sodium channel, NaV1.8, resulted in a time‐dependent uptake of the ODN by dorsal root ganglion (DRG) neurons, and a selective ‘knock‐down’ of the expression of NaV 1.8 which reversed neuropathic pain induced by spinal nerve injury.