L
Liam Good
Researcher at Royal Veterinary College
Publications - 100
Citations - 5050
Liam Good is an academic researcher from Royal Veterinary College. The author has contributed to research in topics: Peptide nucleic acid & Gene. The author has an hindex of 35, co-authored 95 publications receiving 4459 citations. Previous affiliations of Liam Good include University of London & University of Delhi.
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Journal ArticleDOI
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
Claes Wahlestedt,Peter Salmi,Liam Good,Johanna Kela,Thomas Johnsson,Tomas Hökfelt,Christian Broberger,Frank Porreca,Josephine Lai,Kunkun Ren,Michael H. Ossipov,Alexei A. Koshkin,Nana Jakobsen,Jan Skouv,Henrik Oerum,Mogens Havsteen Jacobsen,Jesper Wengel +16 more
TL;DR: It is demonstrated here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents, and LNA/DNA copolymers exhibited potent antisense activity on assay systems as disparate as a G-protein-coupled receptor in living rat brain and an Escherichia coli reporter gene.
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Bactericidal antisense effects of peptide–PNA conjugates
TL;DR: Results indicate that peptides can be used to carry antisense PNA agents into bacteria and open exciting possibilities for anti-infective drug development and provide new tools for microbial genetics.
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Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA
Liam Good,Peter E. Nielsen +1 more
TL;DR: The results demonstrate gene- and sequence-specific antisense inhibition in E. coli and open possibilities for anti-sense antibacterial drugs and gene function analyses in bacteria.
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Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA
Liam Good,Peter E. Nielsen +1 more
TL;DR: It is reported that PNAs targeted to functional and accessible sites in ribosomal RNA can inhibit translation in an Escherichia coli cell-free transcription/translation system, with 50% reductions caused by nanomolar PNA concentrations.
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The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes
Kantaraja Chindera,Manohar Mahato,Ashwani Kumar Sharma,Harry Horsley,Klaudia Kloc-Muniak,Nor Fadhilah Kamaruzzaman,Nor Fadhilah Kamaruzzaman,Satish Kumar,Alexander McFarlane,Jem Stach,Thomas Bentin,Liam Good +11 more
TL;DR: How the widely used antimicrobial polyhexamethylene biguanide kills bacteria selectively over host cells is examined and selective chromosome condensation provides an unanticipated paradigm for antimicrobial action that may not succumb to resistance.