L
Lilian Akello Obwolo
Researcher at Howard University
Publications - 4
Citations - 97
Lilian Akello Obwolo is an academic researcher from Howard University. The author has contributed to research in topics: Viral replication & Endosome. The author has an hindex of 3, co-authored 3 publications receiving 58 citations.
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Journal ArticleDOI
Molecular cloning and characterization of the genes encoding the proteins of Zika virus.
Wangheng Hou,Ruth Cruz-Cosme,Najealicka Armstrong,Lilian Akello Obwolo,Fayuan Wen,Wenhui Hu,Min-Hua Luo,Qiyi Tang +7 more
TL;DR: The chemical features, suborganelle distribution and potential function of each protein using Flag-tagged protein expression system suggest that ZIKV generates 10 functional viral proteins that exhibit distinctive subcellular distribution in host cells.
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Determination of the Cell Permissiveness Spectrum, Mode of RNA Replication, and RNA-Protein Interaction of Zika Virus
Wangheng Hou,Najealicka Armstrong,Lilian Akello Obwolo,Michael Thomas,Xiaowu Pang,Kevin S. Jones,Qiyi Tang +6 more
TL;DR: The results imply that the E protein may be important for viral RNA replication, and provide the insight into the viral RNA-E protein interaction that may be targeted for intervention by designing small molecule drugs.
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Zika virus increases mind bomb 1 levels, causing degradation of pericentriolar material 1 (PCM1) and dispersion of PCM1-containing granules from the centrosome.
Fayuan Wen,Najealicka Armstrong,Wangheng Hou,Ruth Cruz-Cosme,Lilian Akello Obwolo,Koko Ishizuka,Hemayet Ullah,Min-Hua Luo,Akira Sawa,Qiyi Tang +9 more
TL;DR: It is hypothesized that ZIKV infection induces proteasomal PCM1 and CEP131 degradation and thereby disrupts the PCM granules, and shows that ZikV infection increases levels of mind bomb 1 (MIB1) and fails to degrade or disperse PCM in MIB1-ko cells.
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Syncytial and Congregative Effects of Dengue and Zika Viruses on the Aedes Albopictus Cell Line Differ among Viral Strains
TL;DR: In this paper , the authors examined the cytopathic effects of the strains of DENV and ZIKV on C6/36 mosquito cells, a widely used laboratory model for studying infection with these viruses.