Liliana Batista-Nascimento

TL;DR: The latest knowledge on the role of oxidative stress in neurodegenerative disorders, with emphasis on AD and PD, is summarized and an overview of the work undertaken to study AD andPD in yeast is provided, focusing the use of this model to understand the effect of oxidative Stress in both diseases.

TL;DR: Saccharomyces cerevisiae, as the best understood eukaryotic organism, has already begun to play a role in the neurological disorders; thus it could perhaps become a valuable tool also to study the metalloneurobiology.

TL;DR: Yap1 is also involved in the removal of ROS (reactive oxygen species) generated by arsenic compounds, and results point to an additional level of Yap1 contribution to arsenic stress responses by preventing oxidative damage in cells exposed to these compounds.

TL;DR: Yeast cells will be a powerful experimental tool for deciphering aspects of human HSF1 regulation by post-translational modifications.

TL;DR: It is shown that Ca(2+) enhances the tolerance of the wild-type and arsenic-sensitive yap1 strains to arsenic stress in a Crz1-dependent manner, thus providing the first evidence that Ca (2+) signalling cascades are involved in arsenic stress responses.