L
Limin Shi
Researcher at California Institute of Technology
Publications - 4
Citations - 1670
Limin Shi is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Offspring & Respiratory infection. The author has an hindex of 4, co-authored 4 publications receiving 1550 citations.
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Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring
TL;DR: It is found that respiratory infection of pregnant mice with the human influenza virus yields offspring that display highly abnormal behavioral responses as adults, as in schizophrenia and autism, and maternal injection of the synthetic double-stranded RNA polyinosinic-polycytidylic acid causes a PPI deficit in the offspring in the absence of virus.
Journal ArticleDOI
Prenatal Viral Infection Leads to Pyramidal Cell Atrophy and Macrocephaly in Adulthood: Implications for Genesis of Autism and Schizophrenia
S. Hossein Fatemi,J A Earle,Reena Kanodia,David A. Kist,Effat S. Emamian,Paul H. Patterson,Limin Shi,Robert W. Sidwell +7 more
TL;DR: It is shown for the first time that prenatal exposure of pregnant mice on Day 9 of pregnancy to a sublethal intranasal administration of influenza virus has both short-term and long-lasting deleterious effects on developing brain structure in the progeny as evident by altered pyramidal and nonpyramidal cell density values.
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Activation of the maternal immune system alters cerebellar development in the offspring
TL;DR: The cerebellar pathology observed in the offspring of influenza- or poly(I:C)-exposed mice is strikingly similar to that observed in autism, and indicates that deficits are likely caused by the activation of the maternal immune system.
Journal ArticleDOI
Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus
TL;DR: RT–PCR was used to assay various maternal and fetal tissues for influenza A mRNAs coding for neuraminidase, non‐structural protein 2, nuclear protein and matrix protein to determine the extent of viral spread following maternal respiratory infection.