Lin Pan

TL;DR: This study demonstrates for the first time a prebiotic effect of ECP on gut microbiota and forms the basis for the development of E CP as a novel gut microbiota modulator for health promotion and disease management.

TL;DR: A brief overview of carbohydrate-based drug development can be found in this paper, where the authors provide an overview of the recently approved drugs and emerging techniques related to CBDD, including enzymatic synthesis, metabolic engineering, site-specific glycoconjugation, carbohydrate libraries and microarrays.

TL;DR: In this article, the anti-obesity effect of polysaccharide from Enteromorpha clathrata (ECP) was investigated in high-fat diet (HFD)-fed mice and the results showed that ECP significantly reduced the body weight and decreased the serum levels of triacylglycerol and cholesterol.

TL;DR: This article showed that Bacteroides-dominated microbiota is more proficient at degrading polyguluronate and polymannuronate acid (PM) compared to Prevotella-dominated and Escherichia-dominated microbial communities.

TL;DR: It is found that HA is readily fermented by human gut microbiota but with differing fermentative activities among individuals, and forms the basis for understanding the bioavailability of HA from a gut microbiota perspective.