L
Lin Xie
Researcher at Buck Institute for Research on Aging
Publications - 73
Citations - 10846
Lin Xie is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Neurogenesis & Subventricular zone. The author has an hindex of 45, co-authored 68 publications receiving 10250 citations.
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Journal ArticleDOI
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
TL;DR: Findings implicate the angiogenesis factor VEGF in neurogenesis as well in murine cerebral cortical cultures and in adult rat brain in vivo.
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VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
TL;DR: In the ischemic brain VEGF exerts an acute neuroprotective effect, as well as longer latency effects on survival of new neurons and on angiogenesis, and that these effects appear to operate independently.
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Increased hippocampal neurogenesis in Alzheimer's disease
Kunlin Jin,Alyson Peel,Xiao Ou Mao,Lin Xie,Barbara A. Cottrell,David C. Henshall,David A. Greenberg +6 more
TL;DR: It is suggested that neurogenesis is increased in AD hippocampus, where it may give rise to cells that replace neurons lost in the disease, and that stimulating hippocampal neuroGenesis might provide a new treatment strategy.
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Evidence for stroke-induced neurogenesis in the human brain
Kunlin Jin,Xiaomei Wang,Lin Xie,Xiao Ou Mao,Wei Zhu,Yin Wang,Jian-feng Shen,Ying Mao,Surita Banwait,David A. Greenberg +9 more
TL;DR: It is reported that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels.
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Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum.
TL;DR: The results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery.