L
Lin Zhao
Researcher at Sichuan University
Publications - 14
Citations - 338
Lin Zhao is an academic researcher from Sichuan University. The author has contributed to research in topics: Endosome & Protein kinase B. The author has an hindex of 8, co-authored 13 publications receiving 137 citations.
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Journal ArticleDOI
Targeted protein degradation: mechanisms, strategies and application
TL;DR: In this article , the authors summarize recent advances of major targeted protein degradation (TPD) technologies, discuss their potential applications, and hope to provide a prime for both biologists and chemists who are interested in this vibrant field.
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Mechanism of cargo recognition by retromer-linked SNX-BAR proteins.
Xin Yong,Lin Zhao,Wankun Deng,Hongbin Sun,Xue Zhou,Lejiao Mao,Wenfeng Hu,Xiaofei Shen,Qingxiang Sun,Daniel D. Billadeau,Yu Xue,Da Jia +11 more
TL;DR: These studies establish that SNX-BARs function as a direct cargo-selecting module for a large set of transmembrane proteins transiting the endosome, in addition to their roles in phospholipid recognition and biogenesis of tubular structures.
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Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions.
TL;DR: Up-to-date knowledge about this trafficking pathway is summarized, in particular, mechanisms of cargo recognition at endosomes and vesicle tethering at the TGN, and contributions of ER-endosome contacts are summarized.
Journal ArticleDOI
Total flavonoids from sea buckthorn ameliorates lipopolysaccharide/cigarette smoke-induced airway inflammation.
Qing-cuo Ren,Qing-cuo Ren,Xuan‐hao Li,Qiuyue Li,Hailing Yang,Hongling Wang,Hai Zhang,Lin Zhao,Si‐lang Jiang‐yong,Xianli Meng,Yi Zhang,Xiaofei Shen +11 more
TL;DR: TFSB exerts a potent protective effect against LPS/CS‐induced airway inflammation through inhibition of ERK, PI3K/Akt, and PKCα pathways, suggesting that TFSB may be a novel therapeutic agent for respiratory diseases.
Journal ArticleDOI
SNX27-FERM-SNX1 complex structure rationalizes divergent trafficking pathways by SNX17 and SNX27.
Xin Yong,Lin Zhao,Wenfeng Hu,Qingxiang Sun,Hyoungjun Ham,Zhe Liu,Jie Ren,Zhen Zhang,Yifei Zhou,Qin Yang,Xianming Mo,Junjie Hu,Daniel D. Billadeau,Da Jia +13 more
TL;DR: In this paper, the authors showed that the FERM domain of SNX27 is functionally distinct from SNX17 and interacts with a novel DLF motif localized within the N terminus of the SNX1/2 instead of the NPxY/NxxY motif.