L
Lina Holmquist
Researcher at James Cook University
Publications - 3
Citations - 364
Lina Holmquist is an academic researcher from James Cook University. The author has contributed to research in topics: Second messenger system & Proinflammatory cytokine. The author has an hindex of 3, co-authored 3 publications receiving 341 citations.
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Journal ArticleDOI
Lipoic acid as a novel treatment for Alzheimer's disease and related dementias
Lina Holmquist,Grant Stuchbury,Katrin Berbaum,Sonja Muscat,Simon A. Young,Klaus Hager,Jürgen Engel,Gerald Münch +7 more
TL;DR: The properties of LA are explored with particular emphasis on how this agent, particularly the R-alpha-enantiomer, may be effective to treat AD and related dementias.
Journal ArticleDOI
Plant‐derived polyphenols attenuate lipopolysaccharide‐induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages
Kirubakaran Shanmugam,Lina Holmquist,Megan L. Steele,Grant Stuchbury,Katrin Berbaum,Oliver Schulz,Obdulio Benavente Garcia,Julián Castillo,James N. Burnell,Vernon Garcia Rivas,Geoff Dobson,Gerald Muench +11 more
TL;DR: Flavonoids were able to down-regulate LPS-induced tumour necrosis factor production and flavonoids with a 4'-OH substitution in the B-ring are more potent than those with a 3'-OH-4'-methoxy substitution, and flav onoids of the flavone type (with a C2=C3 double bond) are more powerful than those of the flavourside type ( with a at C2-C3 single bond).
Book ChapterDOI
Hydrogen peroxide is a true first messenger
TL;DR: It is shown that hydrogen peroxide is also able to transmit pro-inflammatory signals from one cell to the other and that this action can be inhibited by extracellularly added catalase.