L
Linda S. Powers
Researcher at University of Arizona
Publications - 185
Citations - 7002
Linda S. Powers is an academic researcher from University of Arizona. The author has contributed to research in topics: Extended X-ray absorption fine structure & Heme. The author has an hindex of 50, co-authored 184 publications receiving 6508 citations. Previous affiliations of Linda S. Powers include Roy J. and Lucille A. Carver College of Medicine & University of Iowa.
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Journal ArticleDOI
Vitamin D Decreases Respiratory Syncytial Virus Induction of NF-κB–Linked Chemokines and Cytokines in Airway Epithelium While Maintaining the Antiviral State
Sif Hansdottir,Martha M. Monick,Nina Lovan,Linda S. Powers,Alicia K. Gerke,Gary W. Hunninghake +5 more
TL;DR: It is found that vitamin D decreases the inflammatory response to viral infections in airway epithelium without jeopardizing viral clearance, suggesting that adequate vitamin D levels would contribute to reduced inflammation and less severe disease in RSV-infected individuals.
Journal ArticleDOI
Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin
Martha M. Monick,Timur O. Yarovinsky,Linda S. Powers,Noah S. Butler,A. Brent Carter,Gunnar Gudmundsson,Gary W. Hunninghake +6 more
TL;DR: It is suggested that RSV infection sensitizes airway epithelium to a subsequent environmental exposure (LPS) by altered expression and membrane localization of TLR4 and has the potential to profoundly alter airway inflammation.
Journal ArticleDOI
Respiratory Syncytial Virus Induces TLR3 Protein and Protein Kinase R, Leading to Increased Double-Stranded RNA Responsiveness in Airway Epithelial Cells
Dayna J. Groskreutz,Martha M. Monick,Linda S. Powers,Timur O. Yarovinsky,Dwight C. Look,Gary W. Hunninghake +5 more
TL;DR: These studies demonstrate that RSV infection of A549 and human tracheobronchial epithelial cells increases the amounts of TLR3 and PKR in a time-dependent manner, which leads to increased NF-κB activity and production of the inflammatory cytokine IL-8 following a later exposure to dsRNA.
Journal ArticleDOI
Identification of an Autophagy Defect in Smokers’ Alveolar Macrophages
Martha M. Monick,Linda S. Powers,Katherine Walters,Nina Lovan,Michael S. Zhang,Alicia K. Gerke,Sif Hansdottir,Gary W. Hunninghake,Gary W. Hunninghake +8 more
TL;DR: The autophagy pathway is identified as a potential target for interventions designed to decrease infection rates in smokers and possibly in individuals with high environmental particulate exposure.
Journal ArticleDOI
Variable airway responsiveness to inhaled lipopolysaccharide.
Joel N. Kline,J D Cowden,Gary W. Hunninghake,Brian C. Schutte,Janet L. Watt,Christine L. Wohlford-Lenane,Linda S. Powers,Michael P. Jones,David A. Schwartz +8 more
TL;DR: It is demonstrated that an LPS phenotype can be reproducibly elicited in humans, which creates an opportunity to identify genes involved in this response to inhaled LPS.