L
Lindsay A. Matthews
Researcher at McMaster University
Publications - 9
Citations - 156
Lindsay A. Matthews is an academic researcher from McMaster University. The author has contributed to research in topics: DNA replication & Saccharomyces cerevisiae. The author has an hindex of 6, co-authored 8 publications receiving 122 citations.
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Journal ArticleDOI
FHA domains: Phosphopeptide binding and beyond
TL;DR: This review presents structural and biochemical work that has unveiled novel interaction interfaces on FHA domains and discusses how these non-canonical interactions modulate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization - events that collectively determine FHA function.
Journal ArticleDOI
Dbf4: the whole is greater than the sum of its parts.
Lindsay A. Matthews,Alba Guarné +1 more
TL;DR: This review summarizes recent genetic, biochemical and structural work delineating the multiple interactions mediated by Dbf4 and its various functions during the cell cycle and discusses how the limited sequence conservation of DBF4 may be an advantage to regulate the activities of multiple cell cycle kinases.
Journal ArticleDOI
Saccharomyces cerevisiae Dbf4 has unique fold necessary for interaction with Rad53 kinase.
TL;DR: The structure reveals that previously characterized Dbf4 mutants with checkpoint phenotypes destabilize the domain, indicating that its structural integrity is essential for the interaction with Rad53.
Journal ArticleDOI
A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins
Lindsay A. Matthews,Rajeevan Selvaratnam,Darryl R. Jones,Madoka Akimoto,Brendan J. McConkey,Giuseppe Melacini,Bernard P. Duncker,Alba Guarné +7 more
TL;DR: The results point to FHA domains functioning as complex logic gates rather than mere phosphoepitope-targeting modules.
Journal ArticleDOI
'AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7.
Ahmad W. Almawi,Lindsay A. Matthews,Larasati,Polina Myrox,Stephen Boulton,Christine Chieh-Lin Lai,Trevor F. Moraes,Giuseppe Melacini,Rodolfo Ghirlando,Bernard P. Duncker,Alba Guarné +10 more
TL;DR: In this article, the N-terminal FHA (FHA1) of Rad53 was shown to interact with Dbf4-dependent kinase (DDK) in the presence and absence of a Cdc7 phosphorylated peptide.