Lindsey T. Saldin

TL;DR: The present manuscript represents a review of ECM hydrogels and attempts to identify structure-function relationships that influence the tissue remodeling outcomes and gaps in the understanding thereof.

TL;DR: Time of flight secondary ion mass spectroscopy (ToF-SIMS) is used to provide sensitive, molecular specific, localized analysis of detergent decellularized biologic scaffolds and demonstrates the importance of maintaining a balance between cell removal and detergent disruption of matrix architecture and matrix surface ligand landscape.

TL;DR: The rheological characterization of an injectable ECM hydrogel and its concentration-dependent delivery into a lesion cavity formed after a stroke based on MRI-guidance is reported, demonstrating the importance of understanding the structure-function relationship of biomaterials to guide particular clinical applications.

TL;DR: Describing the in vitro cellular response and in vivo host response to a homologous esophageal ECM (eECM) versus nonhomologous ECMs derived from small intestinal submucosa and urinary bladder showed that the eECM retains favorable tissue-specific characteristics that enhance the migration of esophages stem cells and supports the formation of 3D organoids to a greater extent than heterologousECMs.

TL;DR: It is demonstrated that the miR-652-5p/miR-7-2-3p signature may serve as a promising prognostic marker in patients with locally advanced EAC.