Showing papers in "Acta Biomaterialia in 2017"

TL;DR: The present manuscript represents a review of ECM hydrogels and attempts to identify structure-function relationships that influence the tissue remodeling outcomes and gaps in the understanding thereof.

TL;DR: Rationally designed and additively manufactured porous metallic biomaterials based on four different types of triply periodic minimal surfaces that mimic the properties of bone to an unprecedented level of multi-physics detail exhibit an interesting combination of topological, mechanical, and mass transport properties.

TL;DR: It is proposed that the next generation of regenerative therapies may evolve from typical biomaterial-, stem cell-, or growth factor-centric approaches to an immune-centric approach.

TL;DR: The fundamental problems encountered in this field are described and recent progress in designing cell-hydrogel hybrid constructs for promoting the reestablishment of osteochondral/cartilage tissues are reviewed.

TL;DR: P pH-responsive drug delivery system could release drug efficiently in targeted acid environment and minimalize the amount of drug release in normal physiological environment and provide the advantage of minimally invasive surgery and high drug-loading ratio.

TL;DR: This work performs a sequence of experimental tests on the same brain specimen to characterize the regional and directional behavior, and supplements these tests with DTI and histology to explore to which extent the macrostructural response is a result of the underlying microstructure.

TL;DR: The aim of this paper is to review for the first time published research investigating the in vivo osseous regenerative capacity of 3D BG scaffolds in bone defect animal models, to better understand and evaluate the progress and future outlook of the use of such scaffolding in BTE.

TL;DR: The most common approaches used for tuning mechanical properties of hydrogels including but are not limited to, interpenetrating polymer networks, nanocomposites, self-assembly techniques, and co-polymerization are discussed.

TL;DR: The most significant biological responses reported in the last 30years, of these BCP-based materials are reviewed to discuss about their exciting future applications as osteoconductive scaffold for delivering various bioactive molecules or bone cells in bone tissue engineering and regenerative medicine.

TL;DR: The aim of this review is to highlight the recent advances (over the past 10years) in developing antimicrobial materials for urinary catheters and to outline future requirements and prospects that guide catheter materials selection and design.

TL;DR: This contribution is significant because it discusses the use of three major bioprinting modalities in vascular tissue biofabrication for the first time in the literature and compares their strengths and limitations in details.

TL;DR: The study shows for the first time that AM of porous Mg may provide distinct possibilities to adjust biodegradation profile through topological design and open up unprecedented opportunities to develop multifunctional bone substituting materials that mimic bone properties and enable full regeneration of critical-size load-bearing bony defects.

TL;DR: A novel framework to understand tendon physiology and pathophysiology is described that may be useful in pushing the field forward and represents a perspective on the important role that biomaterials will play in translating research discoveries to the patient.

TL;DR: These conductive nanofibrous sheets performed the ability to enhance cardiomyocytes maturation and spontaneous beating, and further formed 3D bioactuators with tubular and folding shapes, which indicated their great potential in cardiac tissue engineering and bioactUators applications.

TL;DR: The analysis of the bacterial viability, using different bacterial strains, and the morphological observation of the biofilm produced by the Staphylococcus epidermidis revealed the antimicrobial effectiveness of the Cu-MBG and the relative ionic extracts against both the bacterial growth and theBiofilm formation/dispersion, providing a true alternative to traditional antibiotic systemic therapies.

TL;DR: The desirable physico-chemical properties of the electrospun scaffolds for cardiac therapy are described, and polymers are categorized to natural and synthetic.

TL;DR: A set of post-built surface and heat treatments is presented that can be used to significantly improve the fatigue life of porous SLM-Ti6Al4V samples and a novel and efficient analytical local stress method was developed to accurately quantify the influence of the post- Built treatments on the fatigueLife.

TL;DR: The results provide important information for the use of ACPC-laden hydrogels in regenerative medicine, and pave the way to the biofabrication of 3D constructs with multiple cell types for cartilage regeneration or in vitro tissue models.

TL;DR: The developed GelMA fibrous scaffolds can not only support cell viability and cell adhesion, but also facilitate cell migration and proliferation, accelerating regeneration and formation of cutaneous tissues.

TL;DR: A comparative evaluation of different bioprinting modalities is performed to assess the performance and ability of fabricating 3D tissue models for pharmaceutical use as the critical selection of biop printing modalities plays a crucial role in efficacy and toxicology testing of drugs and accelerates the drug development cycle.

TL;DR: The review rationalizes that the choice of silk protein as a biomaterial is not onlyBecause of its natural polymeric nature, mechanical robustness, flexibility and wide range of cell compatibility but also because of its ability to template the growth of hydroxyapatite, the chief inorganic component of bone mineral matrix, resulting in improved osteointegration.

TL;DR: In vitro and in vivo experiments show that this platform can deliver anti-cancer drugs to target cells, release them intracellular upon NIR irradiation, and effectively eliminate tumors through chemo-photothermal synergistic therapeutic effect, offering a way to harness PDA-based theranostic agents to achieve PA imaging-guided cancer therapy.

TL;DR: A novel dental implant material-dual Zn/Mg ion co-implanted titanium was developed, which was found to have superior osteoinductivity, pro-angiogenic effects and inhibitory effects against oral anaerobes and the possible mechanism were discovered.

TL;DR: This review will focus on in vivo applications of ECM hydrogels and functional outcomes in disease models, as well as discuss considerations for clinical translation.

TL;DR: The results are the first to elucidate the specific effect of each ion from bioceramics on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration, paving the way for the design of functional biomaterials with complex compositions for tissue engineering and regenerative medicine.

TL;DR: The first demonstration that it is feasible to create a urethral construct using 3D bioprinting technology and two kinds of biomaterials achieved mechanical properties equivalent to that of native rabbit urethra is demonstrated.

TL;DR: This is the first comprehensive review of cryogel applications in tissue engineering that includes specific looks at their growing roles as extracellular matrix analogues, incubators, and in bioseparation processes.

TL;DR: The evidence that the more recent inorganic modifications to glass and glass-ceramic biomaterials are able to impart antimicrobial properties alongside the more classical bone bonding and osteoconduction is considered.

TL;DR: A review of methods to reduce phase separation of CPC and the associated constraints, and a review of phase separation mechanisms observed during extrusion of other pastes and the theoretical models used to describe these mechanisms are presented to benefit future attempts to develop injectable calcium phosphate based systems.

TL;DR: Time of flight secondary ion mass spectroscopy (ToF-SIMS) is used to provide sensitive, molecular specific, localized analysis of detergent decellularized biologic scaffolds and demonstrates the importance of maintaining a balance between cell removal and detergent disruption of matrix architecture and matrix surface ligand landscape.