Ling Lin

TL;DR: The metabolically active cancer cells are shown to a unique surface electrostatic pattern that can be used for recovering cancer cells from the circulating blood and other solutions.

TL;DR: The Cancer Serum Atlas provides a wide range of potential biomarkers that serve as targets and standard assays for systematic and high-efficient serological studies of cancer, and the CancerSerum Atlas supported pan-targeted proteomic strategy enables high- efficient biomarker discovery and multi-cancer detection, thus can be a powerful tool for liquid biopsy.

TL;DR: Wang et al. as mentioned in this paper integrated shotgun lipidomics with targeted LC-MRM/MS approach to comprehensively analyze SPL species in various biological samples with high accuracy, which clearly support the sphingolipidomic approach in application to discovering disease biomarker panel as well as deep investigation of biological functions of complex SPLs in mammalian samples.

TL;DR: In this article , the authors used time-resolved and single-cell multi-omics to investigate the macrophage heterogeneity along foam cell formation, which revealed the molecular choreography underlying the divergent cell fate during foam-cell formation and revealed the pathogenesis of atherosclerosis and development of new drug targets.

TL;DR: In this paper , the authors profiled the region-resolved transcriptome and proteome of healthy and dilated cardiomyopathy human myocardial tissue and obtained the deep-coverage dataset consisting 7,605 proteins and 19,880 transcripts in four chambers of the human heart.