Lingyan Zhang

TL;DR: It is concluded that V617F is widespread in MPDs and detection of this acquired mutation is likely to have a major impact on the way patients with MPD are diagnosed, as well as serving as an obvious target for signal transduction therapy.

TL;DR: Although FLT3 abnormalities are uncommon in aCML, SPTBN1-FLT3 is a novel constitutively active tyrosine kinase that appears to responsive to both targeted signal transduction therapy and immunotherapy.

TL;DR: GDM1, derived from a patient with an atypical MPN (aMPN), is identified as being responsive to imatinib, and it is found that GDM1 expresses CSF1, andCSF1 neutralization partially inhibited proliferation, suggesting the importance of both autocrine and intrinsic mechanisms of CSF 1R activation.

TL;DR: It is demonstrated that CLL patients were characterized by the earlier age at onset in China than in the United States (median age at diagnosis: 63 years old) and the neonatal survival prediction systems were superior to international prognostic index for CLL (CLL-IPI) and Binet stage in assessing the overall survival and progression free survival of C LL patients.

TL;DR: It is concluded that denaturing high performance liquid chromatography is a high efficiency and reliable technique for mutation detection of c-kit gene and the detection results would be helpful for the selection of therapy in mastocytosis.