L
Lingyan Zhang
Researcher at University of Southampton
Publications - Â 8
Citations - Â 919
Lingyan Zhang is an academic researcher from University of Southampton. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 3, co-authored 4 publications receiving 889 citations.
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Journal ArticleDOI
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
Amy V. Jones,Sebastian Kreil,Katerina Zoi,Katherine Waghorn,Claire Curtis,Lingyan Zhang,Joannah Score,Rachel Seear,Andrew Chase,Francis H. Grand,Helen E. White,Christine Zoi,Dimitris Loukopoulos,Evangelos Terpos,Elisavet-Christine Vervessou,Beate Schultheis,Michael Emig,Thomas Ernst,Eva Lengfelder,Rüdiger Hehlmann,Andreas Hochhaus,David Oscier,Richard T. Silver,Andreas Reiter,Nicholas C.P. Cross +24 more
TL;DR: It is concluded that V617F is widespread in MPDs and detection of this acquired mutation is likely to have a major impact on the way patients with MPD are diagnosed, as well as serving as an obvious target for signal transduction therapy.
Journal ArticleDOI
A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy.
Francis H. Grand,Sameena Iqbal,Lingyan Zhang,Nigel H. Russell,Andrew Chase,Nicholas C.P. Cross +5 more
TL;DR: Although FLT3 abnormalities are uncommon in aCML, SPTBN1-FLT3 is a novel constitutively active tyrosine kinase that appears to responsive to both targeted signal transduction therapy and immunotherapy.
Journal ArticleDOI
Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1.
Andrew Chase,Beate Schultheis,Sebastian Kreil,J.F.E. Baxter,Claire Hidalgo-Curtis,Amy V. Jones,Lingyan Zhang,Francis H. Grand,Junia V. Melo,Junia V. Melo,Nicholas C.P. Cross +10 more
TL;DR: GDM1, derived from a patient with an atypical MPN (aMPN), is identified as being responsive to imatinib, and it is found that GDM1 expresses CSF1, andCSF1 neutralization partially inhibited proliferation, suggesting the importance of both autocrine and intrinsic mechanisms of CSF 1R activation.
Journal ArticleDOI
Distinct Age-Related Clinical Features and Risk Assessment in Chinese With Chronic Lymphocytic Leukemia
Zheng Tian,Mingyue Liu,Xiaosheng Fang,Xiang-jing Zhou,Peipei Li,Ying Li,Lingyan Zhang,Fang Liu,Ya Zhang,Xin Wang +9 more
TL;DR: It is demonstrated that CLL patients were characterized by the earlier age at onset in China than in the United States (median age at diagnosis: 63 years old) and the neonatal survival prediction systems were superior to international prognostic index for CLL (CLL-IPI) and Binet stage in assessing the overall survival and progression free survival of C LL patients.
Journal Article
[Application of denaturing high performance liquid chromatography to mutation detection of the c-kit gene in mastocytosis].
TL;DR: It is concluded that denaturing high performance liquid chromatography is a high efficiency and reliable technique for mutation detection of c-kit gene and the detection results would be helpful for the selection of therapy in mastocytosis.