Linxiang Zhao

TL;DR: In this article, a method for the one-pot synthesis of multi-ring heterocyclic compounds such as pyrrolo-/pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones from o-aminobenzyl alcohols via a gold(I)-catalyzed tandem coupling/cyclization reaction was developed.

TL;DR: In this article, an efficient and convenient method was developed for the one-pot construction of the complex polycyclic heterocycles pyrrolo[1,2-a:2',1'-c]-/ pyrido[2,1-c]pyrrololo[ 1,2a]quinoxalinones from two simple starting materials via a gold(I)-catalyzed domino reaction.

TL;DR: Cellular assay indicated that compound 43 has no toxicity to neuronal cells, and can effectively inhibit Abeta(1-42)-induced neutrotoxicity and increase the cell viability, and on the basis of these positive results, these novel chemical structures may provide a promising potential for therapeutic applications in AD and other types of neurodegenerative disorders.

TL;DR: A series of novel hetero-aromatic moieties substituted α-amino pyrrole-2-carbonitrile derivatives was designed and synthesized based on structure-activity relationships (SARs) of pyr Role- 2- carbonitrile inhibitors to demonstrate good dipeptidyl peptidase IV (DPP4) inhibitory activities and good efficacy in an oral glucose tolerance test in ICR mice.

TL;DR: DC07090 represents a new non-peptidyl small molecule inhibitor for further development of antiviral therapy against EV71 or other picornaviruses.