Lisa M. McTeague

TL;DR: A common pattern of disruption across major psychiatric disorders that parallels the "multiple-demand network" observed in intact cognition is demonstrated, demonstrated to be transdiagnostically vulnerable to gray matter reduction.

TL;DR: Transdiagnostic patterns of symptomatic distress and neurocognitive performance deficits, concurrent with parallel anomalies of brain structure and function may largely contribute to the real-world socio-occupational impairment common across disorders.

TL;DR: Investigating a potential dose-response relationship between past trauma recurrence and current comorbidity and intensity of physiological reactions to imagery of trauma and other aversive scenarios found PTSD patients exceeded control participants in startle reflex, autonomic responding, and facial expressivity during idiographic trauma imagery.

TL;DR: Adaptive defensive engagement during imagery may be compromised by long‐term dysphoria and stress—a phenomenon with implications for prognosis and treatment planning.

TL;DR: Fear imagery studies with more severe anxiety disorder patients – panic disorder with agoraphobia, generalized anxiety disorder, or anxious patients with comorbid depression – show a blunted, less robust fear potentiated response, suggesting that normal defensive reactivity may be compromised by an experience of long-term stress.