Showing papers by "Lisa Shieh published in 1993"
TL;DR: In this article, the authors found that the polyanhydrides obey a distinct erosion pattern and an erosion zone (the region where material loss occurs) moves from the surface to the center of the discs.
Abstract: Bioerodible polymers play an important role in parenteral drug delivery. They combine the advantage of controlling drug release and being absorbed by the body after fulfilling their task. The mechanism which controls drug release is the erosion of polymer bulk. In order to understand and control the release it is, therefore, essential to know the erosion mechanism of a biodegradable polymer. We found that the polyanhydrides obey a distinct erosion pattern. An erosion zone (the region where material loss occurs) moves from the surface to the center of the discs. The monomers of which these copolymers are composed also seem to play an important role in degradation and erosion.
3 citations