L
Lisette M. Acevedo
Researcher at University of California, San Diego
Publications - 23
Citations - 3418
Lisette M. Acevedo is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 16, co-authored 20 publications receiving 3189 citations. Previous affiliations of Lisette M. Acevedo include Sanford-Burnham Institute for Medical Research & Yale University.
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Journal ArticleDOI
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation
Mariarosaria Bucci,Jean-Philippe Gratton,Radu Daniel Rudic,Lisette M. Acevedo,Fiorentina Roviezzo,Giuseppe Cirino,William C. Sessa +6 more
TL;DR: A chimeric peptide with a cellular internalization sequence fused to the caveolin-1 scaffolding domain was generated and systemic administration of the peptide suppressed acute inflammation and vascular leak to the same extent as a glucocorticoid or an endothelial nitric oxide synthase (eNOS) inhibitor.
Journal ArticleDOI
A role for VEGF as a negative regulator of pericyte function and vessel maturation.
Joshua I. Greenberg,David J. Shields,Samuel Barillas,Lisette M. Acevedo,Eric A. Murphy,Jianhua Huang,Lea Scheppke,Christian Stockmann,Randall S. Johnson,Niren Angle,David A. Cheresh +10 more
TL;DR: A role is defined for VEGF as an inhibitor of neovascularization on the basis of its capacity to disrupt VSMC function and reveals a dichotomous role for V EGF and VEGf-R2 signalling as both a promoter of endothelial cell function and a negative regulator of VSMCs and vessel maturation.
Journal ArticleDOI
MicroRNA-132–mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis
Sudarshan Anand,Bharat Majeti,Lisette M. Acevedo,Eric A. Murphy,Rajesh Mukthavaram,Lea Scheppke,Miller Huang,David J. Shields,Jeffrey N. Lindquist,Philip E. Lapinski,Philip D. King,Sara M. Weis,David A. Cheresh +12 more
TL;DR: It is concluded that miR-132 acts as an angiogenic switch by suppressing endothelial p120RasGAP expression, leading to Ras activation and the induction of neovascularization, whereas the application of anti–miR- 132 inhibits neov vascularization by maintaining vessels in the resting state.
Journal ArticleDOI
VEGF-induced vascular permeability is mediated by FAK
Xiao Lei Chen,Ju-Ock Nam,Ju-Ock Nam,Christine Jean,Christine Lawson,Colin Walsh,Erik T. Goka,Ssang-Taek Lim,Alok Tomar,Isabelle Tancioni,Sean Uryu,Jun-Lin Guan,Lisette M. Acevedo,Sara M. Weis,David A. Cheresh,David D. Schlaepfer +15 more
TL;DR: An inducible knockin mouse model is created to study the contribution of the integrin-associated focal adhesion tyrosine kinase (FAK) signaling on vascular function and establishes a role for FAK as an essential signaling switch within ECs regulating adherens junction dynamics.
Journal ArticleDOI
A new role for Nogo as a regulator of vascular remodeling.
Lisette M. Acevedo,Jun Yu,Hediye Erdjument-Bromage,Robert Q. Miao,Jieun Kim,David Fulton,Paul Tempst,Stephen M. Strittmatter,William C. Sessa +8 more
TL;DR: It is shown that Nogo-B is highly expressed in cultured endothelial and smooth muscle cells, as well as in intact blood vessels, and is a regulator of vascular homeostasis and remodeling.