The invention relates to a quinazoline compound shown as a formula (5) below (the formula (5) is shown in the specification), wherein R is selected from H, halogen, C1-C6 alkyl, or C1-C6 alkoxy; Ar isselected from phenyl, naphthyl or phenanthryl, and the phenyl, the naphthyl, or the phenanthryl all are not replaced or replaced with substituents. The compound has an obvious inflammation inhibitioneffect and good research prospects and application potentiality in the field of medicines. The invention further provides a synthesis method of the quinazoline compound. According to the synthesis method, simple and easily obtainable raw materials are used as reactants, and after two steps of reaction, the aryl-substituted quinazoline compound is obtained. The synthesis method has good application prospects and research value.

Diaryl substituted quinazoline compound and synthesis method thereof

The invention relates to nitrogen-containing heterocyclic compounds which can be used as drug intermediates and are shown in the following formula (5) in the description and further provides a synthesis method of the nitrogen-containing heterocyclic compounds. The synthesis method is completed through two steps of reaction, and a catalyst, an organic ligand, an acidic additive and an organic solvent used in the method are deeply explored and selected, so that the new synthesis method for preparation of the compounds is provided. The method has good research potential and technical value.

Synthesis method of nitrogen-containing heterocyclic drug intermediates

The present invention relates to a fused heterocyclic compound capable of being used as a pharmaceutical intermediate and represented by the following formula (5) defined in the specification, and provides a synthesis method of the fused heterocyclic compound, wherein the synthesis method is completed through a two-step reaction, and the catalyst, the organic ligand, the acidic additive and the organic solvent used in the reaction are deeply explored and selected, such that the completely-new synthesis method is provided for the preparation of the compound, and the good research potential andtechnical value can be achieved

Fused heterocyclic pharmaceutical intermediate synthesis method

The invention relates to a quinazoline compound as shown in formula (5) and capable of being used as a drug intermediate and a synthesizing method of the quinazoline compound. The synthesizing methodhas the advantages that the method is completed through two-step reaction, a catalyst, organic ligands, acid additives and an organic solvent used in the method are deeply explored and selected, a brand new synthesizing method is provided for the preparation of the quinazoline compound, and the method has good research potential and technical value.

Synthesizing method of drug intermediate quinazoline compound

The invention relates to a method for synthesizing a diphenyl substituted quinazoline compound shown as the following formula (III). The method comprises the steps that in a solvent, in the presence of a catalyst, a N-donor ligand, an acid accelerator and alkali, a compound in the following formula (I) and a compound in the following formula (II) react, aftertreatment is carried out after the reaction is finished, and therefore the compound in the formula (III) is obtained. The formula is shown in the description, wherein R1 and R2 are independently selected from H and C1-C6 or C1-C6 alkoxy. According to the method, by means of comprehensive selection and cooperation of a nvoel proper substrate, the catalyst, the N-donor ligand, the acid accelerator, alkali, the solvent and the like, the range of the substrate is widened, the yield is good, and the diphenyl substituted quinazoline compound can be obtained. Therefore, the method has good application prospects and study value in the field of organic chemical synthesis, and the brand new method is provided for synthesis of the compound.

Liu Miaochang

Papers

Method for synthesizing diphenyl substituted quinazoline compound