Patent
Method for synthesizing diphenyl substituted quinazoline compound
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TLDR
In this paper, a method for synthesizing a diphenyl substituted quinazoline compound shown as the following formula (III) is presented, which comprises the steps that in a solvent, in the presence of a catalyst, a N-donor ligand, an acid accelerator and alkali, a compound in the following formulas react, aftertreatment is carried out after the reaction is finished, and therefore the compound is obtained.Abstract:
The invention relates to a method for synthesizing a diphenyl substituted quinazoline compound shown as the following formula (III). The method comprises the steps that in a solvent, in the presence of a catalyst, a N-donor ligand, an acid accelerator and alkali, a compound in the following formula (I) and a compound in the following formula (II) react, aftertreatment is carried out after the reaction is finished, and therefore the compound in the formula (III) is obtained. The formula is shown in the description, wherein R1 and R2 are independently selected from H and C1-C6 or C1-C6 alkoxy. According to the method, by means of comprehensive selection and cooperation of a nvoel proper substrate, the catalyst, the N-donor ligand, the acid accelerator, alkali, the solvent and the like, the range of the substrate is widened, the yield is good, and the diphenyl substituted quinazoline compound can be obtained. Therefore, the method has good application prospects and study value in the field of organic chemical synthesis, and the brand new method is provided for synthesis of the compound.read more
Citations
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References
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Journal ArticleDOI
A route to sterically crowded benzophenone N-aryl imines
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Bridge Orientation as a Selector of Intermolecular Interactions in a Series of Crystalline Isomeric Benzylideneanilines
William H. Ojala,Kendra M. Lystad,Tera L. Deal,Jessica E. Engebretson,Jill M. Spude,Barjeta Balidemaj,Charles R. Ojala +6 more
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