The invention relates to a method for synthesizing a diaryl pyrrole compound. The method comprises a reaction route shown in the specification. The method comprises the following steps: S1, in the presence of a palladium catalyst, organic ligand, an oxidant and an acid compound, enabling a compound of formula (I) and a compound of formula (2) to react in an organic solvent, and performing aftertreatment after the reaction is completed so as to obtain a compound of formula (3); S2, in the organic solvent, enabling the compound of formula (3) to be subjected to a self-cyclization reaction in thepresence of the oxidant, and performing aftertreatment after the reaction is completed so as to obtain a compound of formula (4); S3, in the presence of nitrogen, enabling the compound of formula (4)and a compound of formula (5) to react in the solvent in the presence of the palladium catalyst, the organic ligand, the oxidant and the acid compound, and performing aftertreatment after the reaction is completed so as to obtain a compound of formula (6). By adopting the method, different steps are creatively optimized with multiple technical characteristics, completely new synthesis methods andsynthesis routes are provided for preparation of the compound, and good industrial prospects and potential application values can be achieved.

Method for synthesizing diaryl pyrrole compound

The invention relates to a quinazoline compound shown as a formula (5) below (the formula (5) is shown in the specification), wherein R is selected from H, halogen, C1-C6 alkyl, or C1-C6 alkoxy; Ar isselected from phenyl, naphthyl or phenanthryl, and the phenyl, the naphthyl, or the phenanthryl all are not replaced or replaced with substituents. The compound has an obvious inflammation inhibitioneffect and good research prospects and application potentiality in the field of medicines. The invention further provides a synthesis method of the quinazoline compound. According to the synthesis method, simple and easily obtainable raw materials are used as reactants, and after two steps of reaction, the aryl-substituted quinazoline compound is obtained. The synthesis method has good application prospects and research value.

Diaryl substituted quinazoline compound and synthesis method thereof

The invention relates to nitrogen-containing heterocyclic compounds which can be used as drug intermediates and are shown in the following formula (5) in the description and further provides a synthesis method of the nitrogen-containing heterocyclic compounds. The synthesis method is completed through two steps of reaction, and a catalyst, an organic ligand, an acidic additive and an organic solvent used in the method are deeply explored and selected, so that the new synthesis method for preparation of the compounds is provided. The method has good research potential and technical value.

Synthesis method of nitrogen-containing heterocyclic drug intermediates

The present invention relates to a fused heterocyclic compound capable of being used as a pharmaceutical intermediate and represented by the following formula (5) defined in the specification, and provides a synthesis method of the fused heterocyclic compound, wherein the synthesis method is completed through a two-step reaction, and the catalyst, the organic ligand, the acidic additive and the organic solvent used in the reaction are deeply explored and selected, such that the completely-new synthesis method is provided for the preparation of the compound, and the good research potential andtechnical value can be achieved

Fused heterocyclic pharmaceutical intermediate synthesis method

The invention relates to a quinazoline compound as shown in formula (5) and capable of being used as a drug intermediate and a synthesizing method of the quinazoline compound. The synthesizing methodhas the advantages that the method is completed through two-step reaction, a catalyst, organic ligands, acid additives and an organic solvent used in the method are deeply explored and selected, a brand new synthesizing method is provided for the preparation of the quinazoline compound, and the method has good research potential and technical value.

Synthesizing method of drug intermediate quinazoline compound

The invention relates to a method for synthesizing a diphenyl substituted quinazoline compound shown as the following formula (III). The method comprises the steps that in a solvent, in the presence of a catalyst, a N-donor ligand, an acid accelerator and alkali, a compound in the following formula (I) and a compound in the following formula (II) react, aftertreatment is carried out after the reaction is finished, and therefore the compound in the formula (III) is obtained. The formula is shown in the description, wherein R1 and R2 are independently selected from H and C1-C6 or C1-C6 alkoxy. According to the method, by means of comprehensive selection and cooperation of a nvoel proper substrate, the catalyst, the N-donor ligand, the acid accelerator, alkali, the solvent and the like, the range of the substrate is widened, the yield is good, and the diphenyl substituted quinazoline compound can be obtained. Therefore, the method has good application prospects and study value in the field of organic chemical synthesis, and the brand new method is provided for synthesis of the compound.

Method for synthesizing diphenyl substituted quinazoline compound

The invention relates to a method for synthesizing an indole derivative shown in the formula (III) (please see the specification). The method includes the steps that in a solvent and inertia gas atmosphere, when a catalyst, a nitrogen-containing ligand, an acid accelerator and KF exist, a compound in the formula (I) (please see the specification) and a compound in the formula (II) (please see the specification) are reacted, aftertreatment is carried out after the reaction is completed, and therefore the compound in the formula (III) is obtained, wherein R1 is selected from H or halogen, and R2 is selected from H, C1-C6 alkyl, C1-C6 alkoxy or halogen. According to the method, as a proper substrate, the proper catalyst, the proper nitrogen-containing ligand, the proper acid accelerator, the proper KF, the proper solvent and the like are comprehensively selected and cooperated, the range of the substrate is expanded accordingly, the indole derivative can be obtained with the good yield, the method has good application prospects and research value in the field of organic chemistry synthesis, and a brand new method is provided for synthesis of the compound.

Method for synthesizing indole derivative

The invention relates to a synthetic method of a symmetrically-substituted pyrrole compound as shown in the formula (III). The method comprises the following steps: in a solvent and in the existence of a catalyst, a ligand, an acid compound and an ammonium source compound, performing the reaction of a compound as shown in the formula (I) and a compound as shown in the formula (II), and performing post-treatment after the reaction is ended, thereby obtaining a compound as shown in the formula (III) in the specification, wherein R is H, halogen, alkyl of C1 to C6 or alkoxy of C1 to C6; and X is an alkali metal element. According to the method, by virtue of the comprehensive selection and synergism of the specific catalyst, the ligand, the acid compound, the ammonium source compound and the solvent, the symmetrically-substituted pyrrole compound is obtained in high yield, and the application prospect and the industrialized production potential are good in the field of organic chemical synthesis.

Synthetic method of symmetrically-substituted pyrrole compound

The invention discloses a synthetic method of an isoquinoline compound shown in the formula (I) In the formula (I), R1-R3 are H, C1-C6 alkyl or C1-C6 alkoxy, respectively According to special reaction steps in the synthetic method and unique technical characteristics such as combined selection and interaction of a substrate, a catalyst, a nitrogen-containing ligand, an acidic accelerating agent and 4-dimethylamino pyridine in the steps, a target product can be obtained at a good yield A totally new method is provided for synthesis of an isoquinoline compound, and the method is high in research value and great in application potential

Synthetic method of isoquinoline compound

The invention relates to a synthetic method of a diaryl-replacing pyrrolic nitrogen compound shown in the formula (III). The synthetic method includes the steps that in a solvent and the nitrogen atmosphere, when a catalyst, ligand, an acidic compound and an ammonium source compound exist, a compound in the formula (I) and a compound in the formula (II) are reacted, the product is subjected to aftertreatment after reacting is finished, and the compound (III) (please see the specification) is obtained, wherein R is H, halogen, C1-C6 alkyl, C1-C6 alkoxy or C1-C6 alkoxy, and X is an alkali metal element. According to the synthetic method, the special catalyst, the ligand, the acidic compound and the ammonium source compound are selected, a suitable solvent system is used, the diaryl-replacing pyrrolic nitrogen compound can be obtained with the good yield, and the synthetic method has the good application prospect and the good industrial potential productivity in the organic chemistry synthesis field.

Chen Jiuxi

Papers

Method for synthesizing diphenyl substituted quinazoline compound

Method for synthesizing indole derivative

Synthetic method of symmetrically-substituted pyrrole compound

Synthetic method of isoquinoline compound

Synthetic method of diaryl-replacing pyrrolic nitrogen compound