L
Ljiljana Mladenovic-Lucas
Researcher at Wayne State University
Publications - 5
Citations - 99
Ljiljana Mladenovic-Lucas is an academic researcher from Wayne State University. The author has contributed to research in topics: Lipolysis & Adipose triglyceride lipase. The author has an hindex of 2, co-authored 3 publications receiving 58 citations.
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Journal ArticleDOI
Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes.
TL;DR: A mechanism by which PNPLA3 and its risk variant I148M contribute to intracellular lipid metabolism is demonstrated, thereby inhibiting lipolysis in brown adipocytes and promoting lipid storage.
Journal ArticleDOI
Novel pharmacological probes reveal ABHD5 as a locus of lipolysis control in white and brown adipocytes.
Elizabeth A. Rondini,Ljiljana Mladenovic-Lucas,William R. Roush,Geoff T. Halvorsen,Alex E. Green,James G. Granneman +5 more
TL;DR: The results indicate that the overall pattern of lipolysis controlled by AB HD5 ligands is similar to that of isoproterenol, and that ABHD5 plays a central role in the regulation of adipocytelipolysis.
Journal ArticleDOI
Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility.
Qian Huang,Qian Huang,Wei Li,Qi Zhou,Qi Zhou,Parirokh Awasthi,Caroline Cazin,Yitian Yap,Ljiljana Mladenovic-Lucas,Bo Hu,Pancharatnam Jeyasuria,Ling Zhang,James G. Granneman,Rex A. Hess,Pierre F. Ray,Zine-Eddine Kherraf,Ven Natarajan,Zhibing Zhang +17 more
TL;DR: In this article, the role of LZTFL1 in male fertility was investigated in mice with Biallelic variants of the LZFL1 gene, which exhibited abnormal growth rate and retinal degeneration, typical of BBS phenotype.
Journal ArticleDOI
Molecular Modeling of ABHD5 Structure and Ligand Recognition
Rezvan Shahoei,Susheel Pangeni,Matthew A. Sanders,Huamei Zhang,Ljiljana Mladenovic-Lucas,William R. Roush,Geoff T. Halvorsen,Christopher V. Kelly,James G. Granneman,Yu-ming M. Huang +9 more
TL;DR: This work combines computational and experimental methods to build a 3D structure of Alpha/beta hydrolase domain-containing 5 and suggests that the ABHD5 models created by deep learning-based methods are the best candidate structures for the protein.
Journal ArticleDOI
A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands
Emilio P. Mottillo,Ljiljana Mladenovic-Lucas,Huamei Zhang,Li Zhou,Christopher V. Kelly,Pablo A. Ortiz,James G. Granneman +6 more
TL;DR: In this article , a fluorescence resonance energy transfer (FRET) sensor was developed for LC-acyl-CoAs based on the allosterically regulated interaction between α/β hydrolase domain-containing 5 (ABHD5) and Perilipin 5.