Alex E. Green

TL;DR: In response to a high-fat diet, iβ1β2AKO mice more rapidly developed liver steatosis as well as glucose and insulin intolerance, and AMPK in adipocytes is vital for maintaining mitochondrial integrity, responding to pharmacological agents and thermal stress, and protecting against nutrient-overload-induced NAFLD and insulin resistance.

TL;DR: It is reported that fasting mice lacking skeletal muscle AMPK (AMPK-MKO) results in hypoglycemia and hyperketosis, establishing an essential requirement for skeletal Muscle AMPK-mediated autophagy in preserving blood glucose levels during prolonged fasting as well as maintaining muscle integrity and mitochondrial function during aging.

TL;DR: Physiological inhibition of serotonin synthesis or signaling in key metabolic tissues are potential drug targets for obesity and non-alcoholic fatty liver disease and peripheral serotonin acts as an endocrine factor to promote the efficient storage of energy by upregulating lipid anabolism.

TL;DR: Clinical efficacy studies evaluating the clinical efficacy of Canagliflozin on limiting tumorigenesis in pre-clinical animal models and epidemiological studies on cancer incidence relative to other glucose lowering therapies in clinical populations are supported.

TL;DR: A direct competitive binding radioimmunoassay for DNA has been developed, using 125I-iododeoxyuridine-labelled DNA as the antigen and the serum from a patient with systemic lupus erythematosus.