Lois C. Lamb

TL;DR: Proteins potentiated by epidermal growth factor to induce a transformed phenotype in non-neoplastic rat kidney fibroblasts in cell culture have been isolated from many non-Neoplastic tissues of the adult mouse, including submaxillary gland, kidney, liver, muscle, heart, and brain.

TL;DR: The properties of these intracellular polypeptides from both virally and chemically transformed cells are similar to those described for the Sarcoma growth factors previously isolated from the conditioned medium of sarcoma virus-transformed mouse 3T3 cells, suggesting the definition of a class of transforming growth factors common to tumor cells of different origins.

TL;DR: It is suggested that TGF beta may be an important mediator of the known effects of both TGF alpha and EGF on neoplastic transformation, and chemically modified analogs of EGF also potentiate TGFbeta activity to the extent that they bind to the EGF receptor.

TL;DR: The ability to enhance the growth-stimulating effects of the TGFs is specific to EGF, as insulin, the insulin-like growth factors, platelet-derived growth factor and nerve growth factor do not show this property.

TL;DR: Experimental evidence indicates that the major pathway of retinoic acid metabolism in hamster liver microsomes follows the sequence: retinoIC acid → 4-hydroxy-retinoic Acid → 4 -keto-retinosic acid → more polar metabolites.