L
Lorella Bonaccorsi
Researcher at University of Florence
Publications - 49
Citations - 2196
Lorella Bonaccorsi is an academic researcher from University of Florence. The author has contributed to research in topics: Acrosome reaction & Prostate cancer. The author has an hindex of 30, co-authored 49 publications receiving 2154 citations.
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Journal ArticleDOI
Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane.
Michaela Luconi,Lorella Bonaccorsi,Mario Maggi,Paola Pecchioli,Csilla Krausz,Gianni Forti,Elisabetta Baldi +6 more
TL;DR: A significant correlation exists among affinity constants (as determined by binding studies) and EC50 values for the effects of P, 11betaOHP, and 17alphaOHP on intracellular Ca2+ in fura-2-loaded spermatozoa, strongly indicating the involvement of P-binding sites in the biological effect of the steroid.
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Intracellular events and signaling pathways involved in sperm acquisition of fertilizing capacity and acrosome reaction.
TL;DR: The main signal transduction pathways involved in capacitation and acrosome reaction are summarized and the mechanisms underlying sperm DNA fragmentation are briefly reviewed.
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Androgen Receptor Expression in Prostate Carcinoma Cells Suppresses α6β4 Integrin-Mediated Invasive Phenotype1
Lorella Bonaccorsi,Vinicio Carloni,Monica Muratori,Adriana Salvadori,Augusto Giannini,Marco Carini,Mario Serio,Gianni Forti,Elisabetta Baldi +8 more
TL;DR: It is demonstrated that androgen receptor regulation of adhesion and invasion of prostate cancer cells through modulation of α6β4 integrin expression may be one of the molecular mechanisms responsible of this phenomenon.
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Human sperm activation during capacitation and acrosome reaction: role of calcium, protein phosphorylation and lipid remodelling pathways.
TL;DR: This review summarizes the main signal transduction pathways involved in capacitation and acrosome reaction and exhibits sequence homology with proto-oncogenes that mediate proliferation and differentiation in somatic cells.
Journal ArticleDOI
Intracellular calcium increase and acrosome reaction in response to progesterone in human spermatozoa are correlated with in-vitro fertilization
Csilla Krausz,Lorella Bonaccorsi,Michaela Luconi,Beatrice Fuzzi,Luciana Criscuoli,S. Pellegrini,Gianni Forti,Elisabetta Baldi +7 more
TL;DR: The results indicate that [Ca2+]i and acrosome reaction increases in response to progesterone can be of value in the prediction of sperm fertilizing ability.