Lori A. Worley

TL;DR: Exome capture coupled with massively parallel sequencing is used to search for metastasis-related mutations in highly metastatic uveal melanomas of the eye and implicate loss of BAP1 in uveAL melanoma metastasis and suggest that the BAP 1 pathway may be a valuable therapeutic target.

TL;DR: It is shown that primary uveal melanomas surprisingly cluster into two distinct molecular classes based on gene expression profile, and this molecular classification strongly predicts metastatic death and outperforms other clinical and pathological prognostic indicators.

TL;DR: This trial aimed to establish the safety, tolerability, and recommended phase 2 oral dose of the CCR2 inhibitor PF-04136309 in combination with FOLFIRINOX chemotherapy (oxaliplatin and irinotecan plus leucovorin and fluorouracil) and analysed the primary outcome by intention to treat.

TL;DR: Inflammatory monocyte recruitment is critical to pancreatic cancer progression, and targeting CCR2 may be an effective immunotherapeutic strategy in this disease.

TL;DR: utations occurring exclusively at codon 625 of the SF3B1 gene, encoding splicing factor 3B subunit 1, in low-grade uveal melanomas with good prognosis are described.