L
Li Cao
Researcher at Washington University in St. Louis
Publications - 22
Citations - 2983
Li Cao is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Psoriasis & Single-nucleotide polymorphism. The author has an hindex of 15, co-authored 19 publications receiving 2658 citations.
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Journal ArticleDOI
Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
J. William Harbour,Michael D. Onken,Elisha D.O. Roberson,Shenghui Duan,Li Cao,Lori A. Worley,Katie A. Matatall,Cynthia Helms,Anne M. Bowcock +8 more
TL;DR: Exome capture coupled with massively parallel sequencing is used to search for metastasis-related mutations in highly metastatic uveal melanomas of the eye and implicate loss of BAP1 in uveAL melanoma metastasis and suggest that the BAP 1 pathway may be a valuable therapeutic target.
Journal ArticleDOI
PSORS2 Is Due to Mutations in CARD14
Craig T. Jordan,Li Cao,Elisha D.O. Roberson,Katherine C. Pierson,Chi Fan Yang,Cailin E. Joyce,Caitriona Ryan,Shenghui Duan,Cynthia Helms,Yin Liu,Yongqing Chen,Alison A. McBride,Wuh-Liang Hwu,Jer-Yuarn Wu,Yuan-Tsong Chen,Alan Menter,Raphaela Goldbach-Mansky,Michelle A. Lowes,Anne M. Bowcock +18 more
TL;DR: It is proposed that, after a triggering event that can include epidermal injury, rare gain-of-function mutations in CARD14 initiate a process that includes inflammatory cell recruitment by keratinocytes, which perpetuates a vicious cycle of epidersmal inflammation and regeneration, a cycle which is the hallmark of psoriasis.
Journal ArticleDOI
Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis
Craig T. Jordan,Li Cao,Elisha D.O. Roberson,Shenghui Duan,Cynthia Helms,Rajan P. Nair,Kristina Callis Duffin,Philip E. Stuart,David E. Goldgar,Genki Hayashi,Emily Olfson,Bing Jian Feng,Clive R. Pullinger,John P. Kane,Carol Wise,Raphaela Goldbach-Mansky,Michelle A. Lowes,Lynette Peddle,Vinod Chandran,Wilson Liao,Proton Rahman,Gerald G. Krueger,Dafna D. Gladman,James T. Elder,Alan Menter,Anne M. Bowcock +25 more
TL;DR: Fifteen additional rare missense variants in CARD14 are described, their distribution in seven psoriasis cohorts, and their effects on NF-kB activation and the transcriptome of keratinocytes, to contribute to the understanding of the genetic basis of Psoriasis and illustrate the challenges faced in identifying pathogenic variants in common disease.
Journal ArticleDOI
A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis.
Cynthia Helms,Li Cao,James G. Krueger,Ellen M. Wijsman,Francesca Chamian,Derek Gordon,Michael J. Heffernan,Jil A. Wright Daw,Jason Robarge,Jurg Ott,Pui-Yan Kwok,Alan Menter,Anne M. Bowcock +12 more
TL;DR: Two peaks of strong association with psoriasis on chromosome 17q25 separated by 6 Mb are described and suggest defective regulation of SLC9A3R1 or NAT9 by RUNX1 as a susceptibility factor for Psoriasis.
Journal ArticleDOI
A subset of methylated CpG sites differentiate psoriatic from normal skin.
Elisha D.O. Roberson,Ying Liu,Caitriona Ryan,Cailin E. Joyce,Shenghui Duan,Li Cao,Ann G. Martin,Wilson Liao,Alan Menter,Anne M. Bowcock +9 more
TL;DR: A genome-wide study of altered CpG methylation in psoriatic skin, finding sites with inverse correlations between methylation and nearby gene expression include those of KYNU, OAS2, S100A12, and SERPINB3, whose strong transcriptional up-regulation are important discriminators of psoriasis.