L
Lorne J. Brandes
Researcher at University of Manitoba
Publications - 58
Citations - 1706
Lorne J. Brandes is an academic researcher from University of Manitoba. The author has contributed to research in topics: Histamine & Histamine receptor. The author has an hindex of 26, co-authored 58 publications receiving 1684 citations.
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Journal Article
Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses.
Lorne J. Brandes,R. J. Arron,R. P. Bogdanovic,Jiangang Tong,C. L. F. Zaborniak,G. R. Hogg,R. C. Warrington,Wei Fang,Frank S. LaBella +8 more
TL;DR: Stimulation of fibrosarcoma growth in vivo correlated with a corresponding bell-shaped drug-induced increase in DNA synthesis in vitro was correlated with tumor growth acceleration in vivo.
Journal ArticleDOI
Histamine is an intracellular messenger mediating platelet aggregation.
Satya Saxena,Lorne J. Brandes,Allan B. Becker,Keith J. Simons,Frank S. LaBella,Jon M. Gerrard +5 more
TL;DR: A role for histamine as an intracellular messenger, which in platelets promotes aggregation, is indicated by added histamine, which reversed the inhibition by DPPE or HDC inhibitors on aggregation induced by PMA or collagen.
Journal ArticleDOI
Histamine as an intracellular messenger.
Lorne J. Brandes,Frank S. LaBella,Gary B. Glavin,Frixos Paraskevas,Satya Saxena,Archibald McNicol,Jon M. Gerrard +6 more
Journal ArticleDOI
Evidence that the antiestrogen binding site is a histamine or histamine-like receptor.
TL;DR: The data suggest that the antiestrogen binding site may be, in whole or in part, a receptor for histamine different from H1 and H2, similar to the aminoethyl ether group of antihistamines.
Journal ArticleDOI
Enhanced Cancer Growth in Mice Administered Daily Human-Equivalent Doses of Some H1-Antihistamines: Predictive In Vitro Correlates
Lorne J. Brandes,Robert C. Warrington,R. J. Arron,R. P. Bogdanovic,Wei Fang,Gary Queen,D. Stein,Jiangang Tong,C. L. F. Zaborniak,Frank S. LaBella +9 more
TL;DR: Data demonstrate that the in vitro assays predicted the propensity of each H1-antihistamine to stimulate cancer growth in vivo, and may prove valuable to screen potential tumor growth promoters.