L
Louis E. Henderson
Researcher at Science Applications International Corporation
Publications - 55
Citations - 6154
Louis E. Henderson is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Virus & Peptide sequence. The author has an hindex of 40, co-authored 55 publications receiving 6057 citations. Previous affiliations of Louis E. Henderson include Business International Corporation.
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Journal ArticleDOI
Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins.
Jeffrey L. Rossio,Mark T. Esser,Kalachar Suryanarayana,Douglas K. Schneider,Jr Jw Bess,Gabriela M. Vasquez,Theresa A. Wiltrout,Elena Chertova,MK Grimes,Quentin J. Sattentau,L O Arthur,Louis E. Henderson,J. D. Lifson +12 more
TL;DR: Findings indicate that inactivation via this method results in elimination of infectivity with preservation of conformational and functional integrity of virion surface proteins, including both virally encoded determinants and proteins derived from the host cells in which the virus was produced.
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Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA.
TL;DR: These results show that both copies of the motif are required for normal RNA packaging and for infectivity, and that mutants of this type may have important applications, including nonhazardous materials for research, immunogens in vaccine and immunotherapy studies, and diagnostic reagents.
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Nucleic-acid-chaperone activity of retroviral nucleocapsid proteins: significance for viral replication.
TL;DR: Retrovirus particles contain a small, basic protein, the nucleocapsid (NC) protein, that possesses 'nucleic acid chaperone' activity--that is, the NC protein can catalyze the rearrangement of a nucleic acid molecule into the conformation that has the maximal number of base pairs.
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Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus
Elena Chertova,Julian W. Bess,Bruce Crise,Raymond C. Sowder,Terra M. Schaden,Joanne M. Hilburn,James A. Hoxie,Raoul E. Benveniste,Jeffrey D. Lifson,Louis E. Henderson,Larry O. Arthur +10 more
TL;DR: It is suggested that incorporation of SU-TM complexes into the viral membrane may be the primary factor determining the quantity of SU associated with SIV and HIV-1 virions, rather than shedding of SU from mature virions.
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Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processings, and complete amino acid sequences.
Louis E. Henderson,M A Bowers,Raymond C. Sowder,S.A. Serabyn,Donald G. Johnson,Julian W. Bess,L O Arthur,D K Bryant,Catherine Fenselau +8 more
TL;DR: The MN strain of human immunodeficiency virus type 1 was grown in H9 cells, concentrated by centrifugation, and disrupted, and proteins were purified by reversed-phase high-pressure liquid chromatography to suggest heterogeneity in the virus population.