James A. Hoxie

TL;DR: The largely reciprocal expression of CXCR4 and CCR5 among peripheral blood T cells implies distinct susceptibility of T cell subsets to viral entry by T cell line- Tropic versus macrophage-tropic strains during the course of HIV infection.

TL;DR: A murine monoclonal anti-platelet antibody is developed and characterized that binds to activated platelets, but not to unstimulated platelets and inhibits fibrinogen-mediated platelet aggregation.

TL;DR: It is demonstrated that activated platelets can be reliably detected in whole blood using activation-dependent monoclonal antibodies and flow cytometry and may be useful to assess the degree of platelet activation and the efficacy of antiplatelet therapy in clinical disorders.

TL;DR: The finding that one chemokine receptor can function as a primary viral receptor strongly suggests that the HIV envelope glycoprotein contains a binding site for these proteins and that differences in the affinity and/or the availability of this site can extend the host range of these viruses to include a number of CD4-negative cell types.

TL;DR: Tryptase is the first protease other than trypsin that has been shown to activate human PAR-2, and in contrast, although tryptase clearly activates thrombin receptors in COS-1 cells, it does not appear to cleave endogenous throm bin receptors in platelets or CHRF-288 cells.