L
Luca Mastroberardino
Researcher at University of Zurich
Publications - 10
Citations - 1706
Luca Mastroberardino is an academic researcher from University of Zurich. The author has contributed to research in topics: Aldosterone & Epithelial sodium channel. The author has an hindex of 9, co-authored 10 publications receiving 1648 citations. Previous affiliations of Luca Mastroberardino include University of California, Berkeley & University of California, San Francisco.
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Journal ArticleDOI
Epithelial sodium channel regulated by aldosterone-induced protein sgk.
Sei-yu Chen,Aditi Bhargava,Luca Mastroberardino,Onno C. Meijer,Jian Wang,Patricia Buse,Gary L. Firestone,François Verrey,David A. Pearce +8 more
TL;DR: Sgk (serum and glucocorticoid-regulated kinase), a member of the serine-threonine kinase family, is identified as an aldosterone-induced regulator of ENaC activity, suggesting that sgk plays a central role in ald testosterone regulation of Na+ absorption and thus in the control of extracellular fluid volume, blood pressure, and sodium homeostasis.
Journal ArticleDOI
Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family
Luca Mastroberardino,Benjamin Spindler,Rahel Pfeiffer,Patrick J. Skelly,Jan Loffing,Charles B. Shoemaker,François Verrey +6 more
TL;DR: The permease-related protein E16 is identified as the first light chain of h4F2hc and it is shown that the resulting heterodimeric complex mediates L-type amino-acid transport.
Journal ArticleDOI
Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia.
TL;DR: The characteristics of RNA accumulation and their time courses suggest a possible role of one of these induced RNAs in the mediation of the early effect of aldosterone on Na transport.
Journal ArticleDOI
Ras Pathway Activates Epithelial Na+ Channel and Decreases Its Surface Expression in Xenopus Oocytes
Luca Mastroberardino,Benjamin Spindler,Ian C. Forster,Jan Loffing,Roberta Assandri,Anne May,François Verrey +6 more
TL;DR: The possibility that XK-Ras2A, which is the first regulatory protein known to be transcriptionally induced by aldosterone, could play a role in the control of XENaC function in a Aldosterone target cells is raised.
Journal ArticleDOI
Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanisms
François Verrey,François Verrey,David A. Pearce,David A. Pearce,Rahel Pfeiffer,Rahel Pfeiffer,Benjamin Spindler,Benjamin Spindler,Luca Mastroberardino,Luca Mastroberardino,Vanessa Summa,Vanessa Summa,Marija Zecevic,Marija Zecevic +13 more
TL;DR: The aldosterone-induced increase in sodium reabsorption across tight epithelia can be divided schematically into two functional phases: an early regulatory phase starting after a lag period of 20 to 60 minutes, during which the pre-existing transport machinery is activated, and a late phase which can be viewed as an anabolic action leading to a further amplification/differentiation of the Na+ transport machinery.