L
Lucas G. Fernandez
Researcher at University of Virginia Health System
Publications - 29
Citations - 1151
Lucas G. Fernandez is an academic researcher from University of Virginia Health System. The author has contributed to research in topics: Lung & Reperfusion injury. The author has an hindex of 16, co-authored 29 publications receiving 1034 citations. Previous affiliations of Lucas G. Fernandez include University of Zulia & University of Virginia.
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Journal ArticleDOI
Transdifferentiation of ciliated cells during repair of the respiratory epithelium.
Kwon Sik Park,James M. Wells,Aaron M. Zorn,Susan E. Wert,Victor E. Laubach,Lucas G. Fernandez,Jeffrey A. Whitsett +6 more
TL;DR: It is demonstrated that ciliated epithelial cells spread and transdifferentiate into distinct epithelial cell types to repair the airway epithelium.
Journal ArticleDOI
Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury.
Minqing Zhao,Lucas G. Fernandez,Allan Doctor,Ashish Sharma,Alexander Zarbock,Curtis G. Tribble,Irving L. Kron,Victor E. Laubach +7 more
TL;DR: It is concluded that alveolar macrophages are an essential player in the initiation of acute lung I/R injury and are a major producer/initiator of TNF-alpha, MCP-1, and MIP-2.
Journal ArticleDOI
Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-α during pulmonary ischemia-reperfusion injury
TL;DR: Alveolar type II cells, in conjunction with alveolar macrophage-produced TNF-alpha, contribute to the initiation of acute pulmonary IR injury via a proinflammatory cascade through the release of key chemokines.
Journal ArticleDOI
Influence of catastrophizing, anxiety, and depression on in-hospital opioid consumption, pain, and quality of recovery after adult spine surgery.
Lauren K. Dunn,Marcel E. Durieux,Lucas G. Fernandez,Siny Tsang,Emily E Smith-Straesser,Hasan F Jhaveri,Shauna P Spanos,Matthew R Thames,Christopher D Spencer,Aaron Lloyd,Russell Stuart,Fan Ye,Jacob P Bray,Edward C. Nemergut,Bhiken I. Naik +14 more
TL;DR: Catastrophizing, anxiety, and depression play important roles in modulating postoperative pain and preoperative evaluation of these factors, utilizing a validated tool, helps to identify patients at risk.
Journal ArticleDOI
Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells.
TL;DR: It is found that plasma renin concentration in the mice having only one copy of the angiotensinogen gene is greater than twice wild-type, and this increase is mediated primarily by a modest increase in the proportion of renal glomeruli producing renin in their juxtaglomerular apparatus, rather than by up-regulating renin production in cells already committed to its synthesis.